This article explores the intersectionality of gender, race, patriarchy and neo-capitalism in Chika Unigwe’s On Black Sisters’ Street, examining how gendered labor and economic exploitation shape the experiences of African women. By focusing on themes of gender, immigration, sex work, and intersectionality, the study highlights the systemic oppression embedded within both traditional patriarchal structures and modern capitalist economies. In response to these forces, the novel portrays women’s resistance and agency through survival strategies, empowerment tactics, and the reclaiming of narratives. Literature emerges as a powerful tool for feminist activism, allowing marginalized voices to challenge dominant ideologies. Using postcolonial feminism and intersectionality as theoretical lenses, this study reveals the ways in which Unigwe’s female characters navigate oppression while asserting agency, ultimately reshaping conventional gender roles in transnational contexts. Keywords: African literature, Agency, Gender role, Immigration, Intersectionality, Patriarchy, Postcolonial Feminism, Sex work, Resistance